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Egyptians consumed this fruit at least 6,000 years ago, and several ancient Greek philosophers praised the healing power of grapes -- usually in the form of wine. European folk healers developed an ointment from the sap of grapevines to cure skin and eye diseases.
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In atherosclerosis and tumor initiation, inducible nitric oxide synthase (iNOS) has been implicated in the damage of vascular walls and DNA, respectively.
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Dihydroflavonol reductase (DFR) is a key enzyme involved in anthocyanin biosynthesis and proanthocyanidin synthesis in grape. DFR catalyses the reduction of dihydroflavonols to leucoanthocyanidins in the anthocyanin pathway.
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